New cytotoxic cyclic peroxide acids from Plakortis sp. marine sponge.

نویسندگان

  • Thomas R Hoye
  • Walied M Alarif
  • Salim S Basaif
  • Mohamed Abo-Elkarm
  • Mark T Hamann
  • Amir E Wahba
  • Seif-Eldin N Ayyad
چکیده

Bioassay-guided fractionation of the extract of Jamaican marine sponge Plakortis sp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (1a, 2a, 3a, 4, 5), known plakortides (6,7), known bicyclic lactone (8) and new cyclic peroxide acids (1b, 2b, 3b). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines.

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عنوان ژورنال:
  • ARKIVOC : free online journal of organic chemistry

دوره 2015 5  شماره 

صفحات  -

تاریخ انتشار 2015